Publications

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Selected Publications

Jeng, JY, Carlton, AJ, Goodyear, RJ, Chinowsky, C, Ceriani, F, Johnson, SL, Sung, TS, Dayn, Y, Richardson, GP, Bowl, MR, Brown, SDM, Manor, U*, Marcotti, W AAV-mediated rescue of Eps8 expression in vivo restores hair-cell function in a mouse model of recessive deafness (2022) Molecular Therapy-Methods & Clinical Development.:355-370 *co-senior author DOI: https://doi.org/10.1016/j.omtm.2022.07.012

Fang L, Monroe F, Novak SW, Kirk L, Schiavon CR, Seungyoon BY, Zhang T, Wu M, Kastner K, Latif AA, Lin Z, Shaw A, Kubota Y, Mendenhall J, Zhang Z, Pekkurnaz G, Harris K, Howard J, Manor U. 2021. Deep learning-based point-scanning super-resolution imaging. Nat Methods, 18(4), 406-416.
(Featured in STATnews, PreLights, and KUSI). PMCID: PMC8035334

Schiavon C, Zhang T, Zhao B, Moore AS, Wales P, Andrade L, Wu M, Sung T-C, Dayn Y, Feng JW, Quintero OA, Shadel GS, Grosse R, Manor U. 2020. Actin chromobody imaging reveals sub-organellar actin dynamics. Nat Methods 17(9):917-921.
(Featured in PreLights) PMCID: PMC7746311.

Manor U, Bartholomew S, Golani G, Christenson E, Kozlov M, Higgs H, Spudich J, Lippincott-Schwartz J. 2015. A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division. eLife 4.  PMCID: PMC4574297.

Manor U, Disanza A, Grati M, Andrade L, Lin H, Di Fiore P, Scita G, Kachar B. 2011. Regulation of Stereocilia Length by Myosin XVa and Whirlin Depends on the Actin-Regulatory Protein Eps8. Curr Biol 21(2):167-172. PMCID: PMC3040242.

 

all Publications


Shang, F., Wang, S.C., Gongol, B., Han, S.Y., Cho, Y., Schiavon, C.R., Chen, L., Xing, Y., Zhao, Y., Ning, M., Guo, X., He, F., Lei, Y., Wang, L., Manor, U., Marin, T., Chou, K.T., He, M., Huang, P.H., Shyy, J.Y., Malhotra, A. Obstructive Sleep Apnea-induced Endothelial Dysfunction is Mediated by miR-210. (2022) Am J Respir Crit Care Med. DOI: 10.1164/rccm.202202-0394OC

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Jeng, J.Y., Carlton, A.J., Goodyear, R.J., Chinowsky, C., Ceriani, F., Johnson, S.L., Sung, T.S., Dayn, Y., Richardson, G.P., Bowl, M.R., Brown, S.D.M., Manor, U., Marcotti, W. AAV-mediated rescue of Eps8 expression in vivo restores hair-cell function in a mouse model of recessive deafness (2022) Molecular Therapy-Methods & Clinical Development.:355-370 DOI: https://doi.org/10.1016/j.omtm.2022.07.012

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Ramirez, M.A., Ninoyu, Y., Miller, C., Andrade, L.R., Edassery, S., Bomba-Warczak, E., Ortega, B., Manor, U., Rutherford, M.A., Friedman, R.A., Savas, J.N. Cochlear ribbon synapse maturation requires Nlgn1 and Nlgn3. (2022) iScience. 25(8):104803. DOI: 10.1016/j.isci.2022.104803

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Chassefeyre, R., Chaiamarit, T., Verhelle, A., Novak, S.W., Andrade, L.R., Leitão, A.D.G., Manor, U., Encalada, S.E. Endosomal sorting drives the formation of axonal prion protein endoggresomes. (2021) Science Advances. 7(52):eabg3693. DOI: 10.1126/sciadv.abg3693

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Ma, Z., Lytle, N.K., Chen, B., Jyotsana, N., Novak, S.W., Cho, C.J., Caplan, L., Ben-Levy, O., Neininger, A.C., Burnette, D.T., Trinh, V.Q., Tan, M.C.B., Patterson, E.A., Arrojo E Drigo, R., Giraddi, R.R., Ramos, C., Means, A.L., Matsumoto, I., Manor, U., Mills, J.C., Goldenring, J.R., Lau, K.S., Wahl, G.M., DelGiorno, K.E. Single-cell transcriptomics reveals a conserved metaplasia program in pancreatic injury. (2021) Gastroenterology. DOI: 10.1053/j.gastro.2021.10.027

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Shadel, G.S., Adams, P.D., Berggren, W.T., Diedrich, J.K., Diffenderfer, K.E., Gage, F.H., Hah, N., Hansen, M., Hetzer, M.W., Molina, A.J.A., Manor, U., Marek, K., O’Keefe, D.D., Pinto, A.F.M., Sacco, A., Sharpee, T.O., Shokriev, M.N., Zambetti, S. The San Diego Nathan Shock Center: tackling the heterogeneity of aging. (2021) Geroscience. DOI: 10.1007/s11357-021-00426-x

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Fang, L., Monroe, F., Novak, S.W., Kirk, L., Schiavon, C.R., Yu, S.B., Zhang, T., Wu, M., Kastner, K., Latif, A.A., Lin, Z., Shaw, A., Kubota, Y., Mendenhall, J., Zhang, Z., Pekkurnaz, G., Harris, K., Howard, J., Manor, U. Deep learning-based point-scanning super-resolution imaging. (2021) Nature Methods. DOI: 10.1038/s41592-021-01080-z

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Lei, Y., Zhang, J., Schiavon, C.R., He, M., Chen, L., Shen, H., Zhang, Y., Yin, Q., Cho, Y., Andrade, L., Shadel, G.S., Hepokoski, M., Lei, T., Wang, H., Zhang, J., Yuan, J.X., Malhotra, A., Manor, U., Wang, S., Yuan, Z.Y., Shyy, J.Y. SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2. (2021) Circulation research. DOI: 10.1161/CIRCRESAHA.121.318902


Schiavon, C.R., Shadel, G.S., Manor, U. Impaired Mitochondrial Mobility in Charcot-Marie-Tooth Disease. (2021) Front Cell Dev Biol. 9:624823. DOI: 10.3389/fcell.2021.624823

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Lehman, B.J., Lopez-Diaz, F.J., Santisakultarm, T.P., Fang, L., Shokhirev, M.N., Diffenderfer, K.E., Manor, U., Emerson, B.M. Dynamic regulation of CTCF stability and sub-nuclear localization in response to stress. (2021) PLOS Genetics. 17(1):e1009277. DOI: 10.1371/journal.pgen.1009277

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Schiavon, C.R., Zhang, T., Zhao, B., Moore, A.S., Wales, P., Andrade, L.R., Wu, M., Sung, T.C., Dayn, Y., Feng, J.W., Quintero, O.A., Shadel, G.S., Grosse, R., Manor, U. Actin chromobody imaging reveals sub-organellar actin dynamics. (2020) Nature Methods. DOI: 10.1038/s41592-020-0926-5

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Pan, X., Fang, L., Liu, J., Senay-Aras, B., Lin, W., Zheng, S., Zhang, T., Guo, J., Manor, U., Van Norman, J., Chen, W., Yang, Z. Auxin-induced signaling protein nanoclustering contributes to cell polarity formation. (2020) Nature Communications. 11(1):3914. DOI: 10.1038/s41467-020-17602-w

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Boussaty, E.C., Gillard, D., Lavinsky, J., Salehi, P., Wang, J., Mendonça, A., Allayee, H., Manor, U., Friedman, R.A. The Genetics of Variation of the Wave 1 Amplitude of the Mouse Auditory Brainstem Response. (2020) J Assoc Res Otolaryngol. 21(4):323-336. DOI: 10.1007/s10162-020-00762-3

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DelGiorno, K.E., Chung, C.Y., Vavinskaya, V., Maurer, H.C., Novak, S.W., Lytle, N.K., Ma, Z., Giraddi, R.R., Wang, D., Fang, L., Naeem, R.F., Andrade, L.R., Ali, W.H., Tseng, H., Tsui, C., Gubbala, V.B., Ridinger-Saison, M., Ohmoto, M., Erikson, G.A., O’Connor, C., Shokhirev, M.N., Hah, N., Urade, Y., Matsumoto, I., Kaech, S.M., Singh, P.K., Manor, U., Olive, K.P., Wahl, G.M. Tuft Cells Inhibit Pancreatic Tumorigenesis in Mice by Producing Prostaglandin D2. (2020) Gastroenterology. DOI: 10.1053/j.gastro.2020.07.037

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Badgley, M.A., Kremer, D.M., Maurer, H.C., DelGiorno, K.E., Lee, H.J., Purohit, V., Sagalovskiy, I.R., Ma, A., Kapilian, J., Firl, C.E.M., Decker, A.R., Sastra, S.A., Palermo, C.F., Andrade, L.R., Sajjakulnukit, P., Zhang, L., Tolstyka, Z.P., Hirschhorn, T., Lamb, C., Liu, T., Gu, W., Seeley, E.S., Stone, E., Georgiou, G., Manor, U., Iuga, A., Wahl, G.M., Stockwell, B.R., Lyssiotis, C.A., Olive, K.P. Cysteine depletion induces pancreatic tumor ferroptosis in mice. (2020) Science. 368(6486):85-89. DOI: 10.1126/science.aaw9872

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DelGiorno, K.E., Naeem, R.F., Fang, L., Chung, C.Y., Ramos, C., Luhtala, N., O’Connor, C., Hunter, T., Manor, U., Wahl, G.M. Tuft Cell Formation Reflects Epithelial Plasticity in Pancreatic Injury: Implications for Modeling Human Pancreatitis. (2020) Frontiers in Physiology. 11:88. DOI: 10.3389/fphys.2020.00088

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Chu, Q., Martinez, T.F., Novak, S.W., Donaldson, C.J., Tan, D., Vaughan, J.M., Chang, T., Diedrich, J.K., Andrade, L., Kim, A., Zhang, T., Manor, U., Saghatelian, A. Regulation of the ER stress response by a mitochondrial microprotein. (2019) Nature Communications. 10(1):4883. DOI: 10.1038/s41467-019-12816-z

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Villanueva, J.E., Livelo, C., Trujillo, A.S., Chandran, S., Woodworth, B., Andrade, L., Le, H.D., Manor, U., Panda, S., Melkani, G.C. Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption. (2019) Nature Communications. 10(1):2700. DOI: 10.1038/s41467-019-10563-9

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Shi, Y., Gao, W., Lytle, N.K., Huang, P., Yuan, X., Dann, A.M., Ridinger-Saison, M., DelGiorno, K.E., Antal, C.E., Liang, G., Atkins, A.R., Erikson, G., Sun, H., Meisenhelder, J., Terenziani, E., Woo, G., Fang, L., Santisakultarm, T.P., Manor, U., Xu, R., Becerra, C.R., Borazanci, E., Von Hoff, D.D., Grandgenett, P.M., Hollingsworth, M.A., Leblanc, M., Umetsu, S.E., Collisson, E.A., Scadeng, M., Lowy, A.M., Donahue, T.R., Reya, T., Downes, M., Evans, R.M., Wahl, G.M., Pawson, T., Tian, R., Hunter, T. Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. (2019) Nature. 569(7754):131-135. DOI: 10.1038/s41586-019-1130-6

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Curchoe, C.L., Manor, U. Actin Cytoskeleton-Mediated Constriction of Membrane Organelles via Endoplasmic Reticulum Scaffolding. (2017) ACS Biomater Sci Eng. 3(11):2727-2732. DOI: 10.1021/acsbiomaterials.6b00802

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Graydon, C.W., Manor, U., Kindt, K.S. In Vivo Ribbon Mobility and Turnover of Ribeye at Zebrafish Hair Cell Synapses. (2017) Scientific Reports. 7(1):7467. DOI: 10.1038/s41598-017-07940-z

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Yao, P.J., Manor, U., Petralia, R.S., Brose, R.D., Wu, R.T., Ott, C., Wang, Y.X., Charnoff, A., Lippincott-Schwartz, J., Mattson, M.P. Sonic hedgehog pathway activation increases mitochondrial abundance and activity in hippocampal neurons. (2017) Molecular Biology of the Cell. 28(3):387-395. DOI: 10.1091/mbc.E16-07-0553

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Andrade, L.R., Salles, F.T., Grati, M., Manor, U., Kachar, B. Tectorins crosslink type II collagen fibrils and connect the tectorial membrane to the spiral limbus. (2016) Journal of Structural Biology. 194(2):139-146. DOI: 10.1016/j.jsb.2016.01.006

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Webster, M.T., Manor, U., Lippincott-Schwartz, J., Fan, C.M. Intravital Imaging Reveals Ghost Fibers as Architectural Units Guiding Myogenic Progenitors during Regeneration. (2016) Cell Stem Cell. 18(2):243-252. DOI: 10.1016/j.stem.2015.11.005

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Manor, U., Bartholomew, S., Golani, G., Christenson, E., Kozlov, M., Higgs, H., Spudich, J., Lippincott-Schwartz, J. A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division. (2015) Elife. 4. DOI: 10.7554/eLife.08828

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Orly, G., Manor, U., Gov, N.S. A Biophysical Model for the Staircase Geometry of Stereocilia. (2015) PLOS One. 10(7):e0127926. DOI: 10.1371/journal.pone.0127926

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Quintero, O.A., Unrath, W.C., Stevens, S.M., Manor, U., Kachar, B., Yengo, C.M. Myosin 3A kinase activity is regulated by phosphorylation of the kinase domain activation loop. (2013) Journal of Biological Chemistry. 288(52):37126-37137. DOI: 10.1074/jbc.M113.511014

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Furness, D.N., Johnson, S.L., Manor, U., Rüttiger, L., Tocchetti, A., Offenhauser, N., Olt, J., Goodyear, R.J., Vijayakumar, S., Dai, Y., Hackney, C.M., Franz, C., Di Fiore, P.P., Masetto, S., Jones, S.M., Knipper, M., Holley, M.C., Richardson, G.P., Kachar, B., Marcotti, W. Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2. (2013) Proceedings of the National Academy of Sciences of the United States of America. 110(34):13898-13903. DOI: 10.1073/pnas.1304644110

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Ben Isaac, E., Manor, U., Kachar, B., Yochelis, A., Gov, N.S. Linking actin networks and cell membrane via a reaction-diffusion-elastic description of nonlinear filopodia initiation. (2013) Phys Rev E Stat Nonlin Soft Matter Phys. 88(2):022718. DOI: 10.1103/PhysRevE.88.022718

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Manor, U., Grati, M., Yengo, C.M., Kachar, B., Gov, N.S. Competition and compensation: dissecting the biophysical and functional differences between the class 3 myosin paralogs, myosins 3a and 3b. (2012) Bioarchitecture. 2(5):171-174. DOI: 10.4161/bioa.21733

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Merritt, R.C., Manor, U., Salles, F.T., Grati, M., Dose, A.C., Unrath, W.C., Quintero, O.A., Yengo, C.M., Kachar, B. Myosin IIIB uses an actin-binding motif in its espin-1 cargo to reach the tips of actin protrusions. (2012) Current Biology. 22(4):320-325. DOI: 10.1016/j.cub.2011.12.053

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Manor, U., Disanza, A., Grati, M., Andrade, L., Lin, H., Di Fiore, P.P., Scita, G., Kachar, B. Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8. (2011) Current Biology. 21(2):167-172. DOI: 10.1016/j.cub.2010.12.046

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Quintero, O.A., Moore, J.E., Unrath, W.C., Manor, U., Salles, F.T., Grati, M., Kachar, B., Yengo, C.M. Intermolecular autophosphorylation regulates myosin IIIa activity and localization in parallel actin bundles. (2010) Journal of Biological Chemistry. 285(46):35770-35782. DOI: 10.1074/jbc.M110.144360

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Salles, F.T., Merritt, R.C., Manor, U., Dougherty, G.W., Sousa, A.D., Moore, J.E., Yengo, C.M., Dosé, A.C., Kachar, B. Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to the plus ends of actin filaments. (2009) Nature Cell Biology. 11(4):443-450. DOI: 10.1038/ncb1851

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Naoz, M., Manor, U., Sakaguchi, H., Kachar, B., Gov, N.S. Protein localization by actin treadmilling and molecular motors regulates stereocilia shape and treadmilling rate. (2008) Biophysical Journal. 95(12):5706-5718. DOI: 10.1529/biophysj.108.143453

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Manor, U., Kachar, B. Dynamic length regulation of sensory stereocilia. (2008) Seminars in Cell & Developmental Biology. 19(6):502-510. DOI: 10.1016/j.semcdb.2008.07.006

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